Lupus erythematosus panniculitis (aka lupus erythematosus profundus, LEP) has a storied history. The famed clinician Harry Arnold noted that Kaposi (when he was Kohn) observed nodules in patients with lupus. (1) Debates and controversies ensued for decades, with many authorities thinking that these nodules were subcutaneous sarcoidosis We describe a 16-year old female with lupus erythematosus panniculitis with unusual manifestations. She had noted to have developed erythematous nodules and plaques in the right axilla and inguinal.. Lupus erythematosus panniculitis (LEP), also called lupus erythematosus profundus, is a rare variant of chronic cutaneous lupus erythematosus (CCLE). 1-4 LEP commonly presents in the third-to-sixth decades of life, with female predilection. The most frequent cutaneous manifestations are indurated plaques or subcutaneous nodules, and sometimes ulcerations lupus (lo͞o`pəs), noninfectious chronic disease in which antibodies in an individual's immune system attack the body's own substances. In lupus, known medically as lupus erythematosus, antibodies are produced against the individual's own cells, causing tissue inflammation and cell damage Lupus erythematosus (LE) is termed as an autoimmune chronic condition which involves a spectrum of symptoms. It is a part of the connective tissue diseases. Its cutaneous form is termed as cutaneous lupus erythematosus (CLE). Prevalence of CLE is about 70 cases per 100,000 persons. The least common variety of CLE is lupus profundus (LP)—only.
Lupus erythematosus profundus (LEP) is an unusual form of cutaneous lupus erythematosus (CLE) characterized by multiple subcutaneous induration and associated with considerable physical and psychological morbidity. The heterogeneity of CLE makes it difficult to understand its underlying pathogenesis and represents a therapeutic challenge Lupus panniculitis, or lupus profundus, is a variant of lupus erythematosus that primarily affects subcutaneous fat. In nearly all cases there are deep, erythematous plaques and nodules, and some ulcers, which usually involve the proximal extremities, trunk, breasts, buttocks, and face. Lesions may be tender and painful and frequently heal with. Grossberg E et al (2001) Lupus profundus: not a benign disease. Lupus 10: 514-516; Günther C et al (2011) Infliximab treatment of a patient with lupus erythematosus profundus. Abstract CD 46th DDG meeting: P16/13 ; Hebra F, Kaposi M (1875) On Diseases of the Skin, Including Exanthema. New Sydenham Society, London, 4:1-24 Lupus panniculitis (lupus erythematosus profundus or Kaposi-Irgang disease) is an uncommon form of chronic cutaneous lupus erythematosus that is characterised by chronic, recurrent pannicular.
Conclusion African patients with lupus profundus when compared with other series comprising Asian and white patients showed greater frequency of periorbital edema as the initial manifestation. Review of the literature disclosed that this subset of lupus profundus appears to have a more benign course. View Full Article. Grossberg E et al. (2001) Lupus profundus: not a benign disease. Lupus 10: 514-516; Günther C et al. (2011) Infliximab-Behandlung einer Patientin mit Lupus erythematodes profundus. Abstract-CD 46. DDG-Tagung: P16/13 ; Hebra F, Kaposi M (1875) On Diseases of the Skin, Including Exanthema. New Sydenham Society, London, 4:1-24 Lupus profundus is an unusual clinical variant of cutaneous lupus erythematosus that has previously been described as a benign disease that follows a mild course. This report describes the extent of disease and associated comorbidities in patients with severe lupus profundus and systemic lupus eryth
Lupus profundus is a rare manifestation of cutaneous lupus erythematosus, seen in 1% to 3% of patients. It most commonly presents in association with classic chronic cutaneous lesions of discoid lupus erythematosus; however, such lesions, as well as a clinical history of lupus erythematosus, may be lacking Lupus erythematosus (LE) panniculitis (profundus) is an unusual clinical variant of lupus erythematosus in which the cutaneous inflammatory reaction occurs primarily in the deeper corium. Clinical and immunologic studies have been performed in six patients with LE panniculitis recently observed Lupus erythematosus profundus (LEP) is a clinical subtype of cutaneous lupus erythematosus that has a chronic and recurrent clinical course. Systemic corticosteroids, which are often administered in cases of LEP complicated with systemic lupus erythematosus, are generally effective but cause side effects. Thus, other therapeutic options are needed Lupus erythematosus profundus (LEP) is a rare form of chronic cutaneous lupus erythematosus. We report on a case of a 56-year-old Caucasian woman who presented with a single, persistent, painful rash on the left hip and lateral aspect of the left upper thigh, which had been present for 2.5 years
Lupus profundus/panniculitis can demonstrate overlying DLE histopathologic findings of hyperkeratosis, hydropic degeneration of the basal layer, perivascular and periappendageal lymphocytic infiltrate and increased mucin deposition (Figure 2). Figure 2 Lupus erythematosus profundus successfully treated with dapsone: review of the literature. Ujiie H, Shimizu T, Ito M, Arita K, Shimizu H. Arch Dermatol, 142(3):399-401, 01 Mar 2006 Cited by: 19 articles | PMID: 16549729. Revie Lupus (loo -pŭs) (Wolf) A constellation in the southern hemisphere near Centaurus, lying partly in the Milky Way, with several stars of 2nd magnitude.There are many naked-eye double stars and several globular and open star clusters. Abbrev.: Lup; genitive form: Lupi; approx. position: RA 15.3h, dec -45°; area: 334 sq deg
Lupus profundus, indeterminate lymphocytic lobular panniculitis and subcutaneous T-cell lymphoma: a spectrum of subcuticular T-cell lymphoid dyscrasia. Magro CM, Crowson AN, Kovatich AJ, Burns F. J Cutan Pathol, 28(5):235-247, 01 May 2001 Cited by: 60 articles | PMID: 1140166 Lupus erythematosus panniculitis (Lupus profundus). Fergin PE, MacDonald DM. Clinical and Experimental Dermatology, 01 Jun 1980, 5(2): 257-260 DOI: 10.1111/j.1365-2230.1980.tb01698.x PMID: 7438520 . Share this article Share with email Share with twitter Share with linkedin Share with facebook. Abstract. lupus (lo͞o`pəs), noninfectious chronic disease in which antibodies in an individual's immune system attack the body's own substances.In lupus, known medically as lupus erythematosus, antibodies are produced against the individual's own cells, causing tissue inflammation and cell damage
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original - Lupus erythematosus profundus/panniculitis (LEP) Intermittent cutaneous lupus erythematosus (ICLE) - Lupus erythematosus tumidus (LET Conclusion African patients with lupus profundus when compared with other series comprising Asian and white patients showed greater frequency of periorbital edema as the initial manifestation. Review of the literature disclosed that this subset of lupus profundus appears to have a more benign course. View Full Article. Systemic lupus erythematosus presenting as panniculitis (lupus profundus). Díaz-Jouanen E, DeHoratius RJ, Alarcón-Segovia D, Messner RP. Ann Intern Med, 82(3):376-379, 01 Mar 1975 Cited by: 42 articles | PMID: 111547
Abstract Background Lupus erythematosus profundus (lupus panniculitis) is a rare variant of lupus erythematosus with predominant involvement of the subcutaneous tissue. There are only a few report.. Wätzig V et al (1989) Lupus panniculitis (Lupus erythematodes profundus). Act Dermatol 15: 109-111; Wimmershoff MB et al (2003) Discoid lupus erythematosus and lupus profundus in childhood: a report of two cases. Pediatric dermatol 20: 140-145; Recommended articles. Advertisment INTRODUCTION. Lupus erythematosus panniculitis (LEP), also called lupus erythematosus profundus, is a rare variant of chronic cutaneous lupus erythematosus (CCLE). 1-4 LEP commonly presents in the third-to-sixth decades of life, with female predilection. The most frequent cutaneous manifestations are indurated plaques or subcutaneous nodules, and sometimes ulcerations
Systemic lupus erythematosus presenting as panniculitis (lupus profundus). Díaz-Jouanen E, DeHoratius RJ, Alarcón-Segovia D, Messner RP. Annals of Internal Medicine, 01 Mar 1975, 82(3): 376-379 DOI: 10.7326/0003-4819-82-3-376 PMID: 1115472 . Share this article Share with. Lipodystrophy is a medical condition of fat metabolism caused by adipose tissue accumulation and lipoatrophy (loss of fat mass). Lipodystrophy can be congenital or acquired Acquired lipodystrophy is the most common form of lipodystrophy. In partial and generalized acquired lipodystrophy, females are affected more often than males SLE /The Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease, with multisystemic involvement. The disease has several phenotypes, with va Lupus erythematosus panniculitis (lupus profundus): Clinical, histopathological, and molecular analysis of nine cases Background: The diagnosis of lupus erythematosus panniculitis (LEP) may be very difficult in cases in which involvement of the subcutaneous fat is the only manifestation of the disease. The main differential diagnosis is. Lupus erythematosus profundus (LEP) is an unusual variant of cutaneous lupus erythematosus (CLE) that is characterized by chronic, recurrent inflammation of the subcutaneous tissue leading to fibrosis. It is found in the settings of both discoid and systemic lupus erythematosus. Generalized forms are extremely rare
A middle aged female presented with swelling of face and periorbital region for 4 weeks and fever 3 weeks diagnosed and treated as cellulitis elsewhere examination revealed periorbital puffiness and indurated lesions on face with complete distortion of facial features. Labs-hb- 10.7 gm/dl Tlc-4500/cumm Plt- 160×10^3/microlitre Sr creatinine-0.8 mg/dl Lft- sgot −87 u/L, sgpt-64 u/l Ana if. Lupus erythematosus profundus (LEP) is a subtype of chronic cutaneous LE with or without systemic lupus erythematosus (SLE). Additionally, LEP is rarely seen in patients with connective tissue diseases other than SLE. Association between LEP and systemic sclerosis (SSc). After 11 years from the onset of developing lupus profundus the patient described here began to intermittently express hematological and serological f.. Home. Journals. A-Z Journals Browse By Subject. Guidelines & Policies . Editorial Policies Online Submission Instructions to Authors Policies Publication ethics Reviewers Terms and Conditions Bacanli A, Uzun S, Ciftcioglu MA, Alpsoy E (2005) A case of lupus erythematosus profundus with unusual manifestations. Lupus 14:403. Article CAS PubMed Google Scholar 18. Chen MT, Chen KS, Chen MJ et al (1999) Lupus profundus (panniculitis) in a chronic haemodialysis patient. Nephrol Dial Transplant 14:966-96 Lupus erythematosus profundus is a rare subtype of CCLE and involves lesions of the subcutaneous fat tissue 1,7 whereas ChLE is a rare acral variant of CCLE that typically affects the fingers.
Lupus erythematosus — Classification and external resources ICD 10 L93 (ILDS L93.010) ICD 9 695.4 Lupus erythematosus Wikipedia. lupus panniculitis — lupus erythematosus panniculitis lupus erythematosus profundus Medical dictionar Lupus panniculitis can occur above the waist and is less likely to be associated with SLE. The lesions result in depressed areas, and when associated with DLE lesions overlying them, are known as lupus profundus. Chilblains lupus presents with erythematous tender plaques on fingers and toes
Lupus Erythematosus Profundus. LEP, historically referred to as Kaposi-Irgang disease or also known as lupus pan-niculitis, is a rare variant of CCLE in which pathologic changes occur primarily in the lower dermis and subcutaneous tissue. In 1883, subcutaneous nodules associated with LE were first described by Kaposi (Kaposi 1883), but the. LEP, also known as Kaposi-Irgang lupus erythematosus profundus, is a rare skin condition originally described by Kaposi in 1883 and later by Irgang in1940. 1 It is a clinical variant of LE primarily affecting the deep dermis and subcutaneous fat.It may occur on its own or along with discoid lupus erythematosus (DLE) or SLE. LEP is more prevalent in the age group of 20-60 years Lupus erythematosus panniculitis or lupus erythematosus profundus is characterized by inflammation of the deep dermis and subcutaneous tissue. It can occur in isolation or associated with chronic systemic or discoid lupus erythematosus. It usually consists of nodules and hardened subcutaneous plaques on the forehead, cheeks, proximal. Lupus profundus consists of deep brawny indurations or subcutaneous nodules occur under normal or, less often, involved skin; the overlying skin may be erythematous, atrophic, ulcerated, and, on healing, may leave a depressed scar (Figure 6). The most common sites of involvement are proximal extremities, particularly the lateral aspects of the. DLE can also occur as a manifestation of SLE in approximately 20% of patients. Other less common forms of chronic cutaneous lupus erythematosus include hypertrophic lupus erythematosus, tumid lupus erythematosus, lupus erythematosus panniculitis (LEP or lupus profundus), oral DLE, as well as DLE lesions on the palms and/or soles
Keywords: Discoid lupus erythematosus, lupus mastitis, lupus profundus, systemic lupus erythematosus. How to cite this article: Vineetha M, Palakkal S, Sobhanakumari K, Celine M I. Interchanging autoimmunity - lupus mastitis coexisting with systemic polyarteritis nodosa. Indian J Dermatol 2016;61:200- Clinical appearance was unusual but histological examination revealed linear lupus erythematosus profundus. To our knowledge, only one other case of linear lupus erythematosus profundus on the scalp has been reported in English written literature until now. Original language: English: Pages (from-to
Hypertrophic lupus erythematosus was described by Bechet in 1942 as lupus erythematosus hypertrophicus et profundus, with the latter descriptor emphasizing the depth of the infiltrate. 1 However, this is not to be confused with lupus profundus, as there is no panniculitic component present in HLE Vesicular cutaneous lupus erythematosus Historical perspective. First recognized in the late 1960's, hidradenitis suppurativa was a unique skin disease described in Collies, Shetland sheepdogs and their crosses [15, 16].Since the early 1980's, the disease mentioned above was suspected to represent, in fact, bullous pemphigoid [17, 18] or erythema multiforme in these breeds [19, 20] 3. Discussion. Systemic lupus erythematosus is a systemic autoimmune disease that can affect multiple organs. It is clinically characterized by repeated lupus activities, which can affect the skin, muscles and joints, heart, lungs, kidneys, nervous system, blood system, etc. Almost all patients with systemic lupus erythematosus are accompanied by kidney damage [1], and approximately 20% of.
Define lupus profundus. lupus profundus synonyms, lupus profundus pronunciation, lupus profundus translation, English dictionary definition of lupus profundus. n. A constellation of stars in the Southern Hemisphere near Centaurus and Scorpius. n. 1. See systemic lupus erythematosus. 2. Any of several other forms of.. Unilateral parotid swelling or mass in the lupus erythematosus profundus person is a rare or under reported clinical scenario in existing literature. This is a case of a 49-year-old man with such presentation for whom medical management of the underlying condition led to the resolution of the swelling. Lupus erythematosus profundus must be considered as a differential diagnosis of unexplained.
Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple organs and systems. Mucocutaneous involvement was described as initial manifestation in up to 81% childhood-onset SLE (cSLE) patients and in up to 100% of them during the disease course [1,2,3].Chronic cutaneous lupus erythematosus was reported as first manifestation in up to 4% cSLE patients and in up to 10%. Introduction. Lupus erythematosus tumidus (LET) is a chronic relapsing inflammatory disease of the skin and was first described by Erich Hoffmann in 1909, 1 presenting two patients with rounded, elevated, erythematous and non-scaling urticarial lesions. This article was followed by a report in 1930 with subsequent reports describing LET in the 1950s. 2,3 LET occurs predominantly on sun exposed. Lupus profundus is a rare skin condition originally described by Kaposi in 1883. It is a clinical variant of LE in which the deep dermis and subcutaneous fat are predominantly affected. A 38-year-old female presented with history of development o TY - JOUR T1 - Lupus erythematosus profundus successfully treated with dapsone: review of the literature. AU - Ujiie,Hideyuki, AU - Shimizu,Tadamichi, AU - Ito,Miki, AU - Arita,Ken, AU - Shimizu,Hiroshi, PY - 2006/3/22/pubmed PY - 2006/4/12/medline PY - 2006/3/22/entrez SP - 399 EP - 401 JF - Archives of dermatology JO - Arch Dermatol VL - 142 IS - 3 SN - 0003-987X UR - https://neuro. Lupus erythematosus profundus, a form of chronic cutaneous lupus erythematosus, is a rare inflammatory disease involving in the lower dermis and... DOAJ is a community-curated online directory that indexes and provides access to high quality, open access, peer-reviewed journals
Lupus profundus, or lupus panniculitis, is a rare variant of lupus erythematosus. It involves the subcutaneous adipose tissue, typically presenting as nontender nodules over the face, arms, and. Define lupus panniculitis, lupus profundus. lupus panniculitis, lupus profundus synonyms, lupus panniculitis, lupus profundus pronunciation, lupus panniculitis, lupus profundus translation, English dictionary definition of lupus panniculitis, lupus profundus. n. A constellation of stars in the Southern Hemisphere near Centaurus and Scorpius A woman aged 45 years presented for evaluation of skin lesions. She reported an 8-9-year history of occasionally tender, waxing-and-waning skin nodules refractory to dapsone, prednisone and methotrexate. Examination revealed multiple indurated subcutaneous nodules distributed on the upper extremities, with scattered patches of lipoatrophy in areas of nodule regression (figure 1) Lupus erythematosus profundus definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now Posted 6/24/2016 4:01 PM (GMT -6) We have only had a few members come thru with Lupus Panniculitis (Profundus), and I don't believe any of them have posted in the last few months. Note that Lupus, in all it's forms, is an auto-immune disease and I know of no studies proving that better eating cures such diseases
Antinuclear antibodies were positive. Histopathology, direct immunofluorescence and immunological assays allowed us to diagnose lupus erythematosus profundus. To our knowledge, only one other case of linear lupus erythematosus profundus has been reported in the literature until now In 1998, Smith and Cyr reviewed the history of lupus in the classical era, which included the derivation of the term lupus, the nature of the butterfly rash, and the description of cutaneous lesions in discoid lupus, lupus vulgaris, and lupus profundus. The word lupus is a Latin word, which means wolf Jennifer Long A lupus rash on the face may be caused by acute cutaneous lupus, which can also cause severe headaches. A lupus rash on the face is most commonly caused by a form of systemic lupus called cutaneous lupus erythmatosus. Three sub-types of cutaneous lupus — chronic, subacute, and acute — are known to cause three different types of rash Linear cutaneous lupus profundus was diagnosed. Laboratory tests were normal, apart from positive antinuclear antibodies (1:200) and slightly increased C3d complement. Under oral hydroxychloroquine therapy the disorder resolved within 12 weeks, followed by complete regrowth of hair. No relapse occurred during 1 year of maintenance treatment Central nervous system manifestations of systemic lupus erythematosus (CNS lupus) describe a wide variety of neuropsychiatric manifestations that are secondary to systemic lupus erythematosus (SLE) in the central nervous system (CNS). For a general discussion, and for links to other system specific manifestations, please refer to the article on systemic lupus erythematosus r/lupus: A community for those suffering from Lupus or other autoimmune illnesses to connect, build community and provide support. This is a safe